Reductive nanocomplex encapsulation of cRGD-siRNA conjugates for enhanced targeting to cancer cells
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چکیده
منابع مشابه
Reductive nanocomplex encapsulation of cRGD-siRNA conjugates for enhanced targeting to cancer cells
In this study, through covalent conjugation and lipid material entrapment, a combined modification strategy was established for effective delivery of small interfering RNA (siRNA). Single strands of siRNA targeting to BRAFV600E gene (siMB3) conjugated with cRGD peptide at 3'-terminus or 5'-terminus via cleavable disulfide bond was synthesized and then annealed with corresponding strands to obta...
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ژورنال
عنوان ژورنال: International Journal of Nanomedicine
سال: 2017
ISSN: 1178-2013
DOI: 10.2147/ijn.s136726